Patients with chronic obstructive pulmonary disease are generally not allowed to drink alcohol, or it is best not to drink alcohol, which may lead to acute exacerbation of chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease is a chronic inflammatory disease of the airways, which can appear in the acute exacerbation of the clinical symptoms of chest tightness, shortness of breath, dyspnea and cough. Drinking alcohol can affect the clinical medication of patients with chronic obstructive pulmonary disease. Patients with chronic obstructive pulmonary disease often have respiratory infections during acute exacerbations, so they need to be treated with the appropriate antibiotics. If cephalosporin antibiotics are used, there is a risk of a disulfiram-like reaction with wine, which can lead to serious reactions, such as chest tightness, shortness of breath, increased dyspnea, or even life-threatening, so patients with chronic obstructive pulmonary disease should try to abstain from alcohol.