Septic osteomyelitis is an infectious disease characterized by pain at the site of the lesion, redness and swelling of the nearby skin, and generalized high fever. Inflammation of bone tissue due to infection by pyogenic bacteria is the main cause of the disease. Clinically, according to different causes of infection, it is divided into two categories: acute and chronic septic osteomyelitis. First, acute septic osteomyelitis: mostly caused by hematogenous or traumatic bacterial invasion of bone tissue infection, the causative organism is mainly Staphylococcus aureus, with generalized high fever and chills, as well as localized redness, swelling and heat pain in the limbs as the main clinical manifestations; Second, chronic septic osteomyelitis: 1, most of them are due to the prolongation of the condition of acute osteomyelitis due to untimely diagnosis and treatment, improper treatment or low immunity and other factors. The patient who has a long course of the disease. Longer course of patients, bones can lose the original normal form, but the performance of the limb distortion deformation, skin pigmentation, and even the occurrence of pathological fracture. 2, a small portion of low virulence pathogenic bacteria can be infected at the beginning of the performance of chronic osteomyelitis, which is mainly characterized by the formation of the four Gu, skin sinus tracts do not heal and continuous pus overflow. When open wounds occur in trauma, it is necessary to carry out timely debridement to prevent infection and enhance the body’s resistance, so that open fractures become closed fractures. Wound dressing change, maintain drainage, strengthen the body resistance and the use of antimicrobial drugs to prevent infection.