A study published online July 23 in The British Journal of Psychiatry suggests that physical activity may safely increase the efficacy of antidepressants in older patients with depressive disorders. The study included patients with depressive disorders aged 65 years or older who were randomized to a 24-week stepwise incremental high-intensity aerobic exercise + sertraline treatment group (S+PAE), a non-incremental low-intensity aerobic exercise + sertraline treatment group (S+NPE), and a sertraline alone treatment group. The primary study endpoint was the rate of depression remission, i.e., the proportion of depression Hamilton Rating Scale scores ≤10. A total of 121 patients were included. At the end of the study, remission rates were 45% in the sertraline alone group, 73% in the S+NPE group, and 81% in the S+PAE group (P=0.001), and the time to remission was shorter in the S+PAE group than in the sertraline group.