Sigmoid colon bulge refers to the elevation of the mucosal surface of the sigmoid colon toward the intestinal lumen, which may be polyps, tumors and other diseases. Sigmoid colon bulge refers to the sigmoid colon mucosal surface toward the intestinal lumen bulging lesion, is a kind of colonoscopy findings, need to be combined with pathological results to determine the specific lesion, may be hyperplastic polyps, inflammatory polyps, adenomatous polyps, or neoplastic diseases. In the case of sigmoid colon bulge, part of the tissue should be cut out under colonoscopic conditions for pathologic examination to clarify the type of disease and receive appropriate treatment. After treatment, regular review is required. Regular colonoscopy should be performed to check the development of the disease. If the disease worsens and develops into cancer, surgical resection should be performed in a timely manner, and further chemotherapy (e.g., 5-FU, furazinouracil, etc.) should be performed after the surgery.