Petechiae on the conjunctiva are one of the clinical manifestations of sepsis. The clinical onset of sepsis is rapid, and the rash is in the form of petechiae, urticaria, impetigo, and scarlet fever-like rash with petechiae on the conjunctiva. Gram-negative cocci sepsis causes petechiae on the conjunctiva of the eye. Since sepsis is mostly secondary to various infections and lacks specific clinical manifestations, it is easy to be missed or misdiagnosed. In order to improve the early diagnosis rate of sepsis, it is necessary to firstly increase the alertness to sepsis and carry out the corresponding examination in suspicious cases in time. Therefore, for those who have fever, elevated total white blood cell count and neutrophils, recent respiratory tract, digestive tract, urinary tract infections or history of burns, instrument operation, and those who fail to obtain effective control of various focal infections despite antimicrobial treatment, the possibility of sepsis should be highly suspected. Positive blood culture is the most reliable diagnostic basis for sepsis. Sepsis itself has no special clinical manifestations, and the manifestations seen in sepsis can also be seen in other acute infections, such as recurring chills or even chills, high fever that can be flaccid or intermittent, petechiae-based rash, arthralgia that involves large joints, mild hepatosplenomegaly, and in severe cases, altered mental status, cardiomyopathies, infectious shock, DIC, and respiratory distress syndrome.