Locally advanced thyroid cancer is generally referred to as locally advanced thyroid cancer. Locally advanced thyroid cancer can be treated, but the chance of cure is small. Generally speaking, thyroid cancer belongs to malignant tumors formed after thyroid cells are over-differentiated. The main treatment for thyroid cancer is surgical removal, which is risky and causes strong irritation to the patient. Usually, the main purpose of treating advanced thyroid cancer is to relieve patients’ discomfort and prolong their life. Because thyroid cancer has a higher degree of differentiation, but after the emergence of metastasis, the deterioration of the disease is slower, and iodine-131 radiation therapy is often used to shrink the tumor. If the patient has metastases to other organs, chemotherapy can be used in combination with radiation therapy. If patients have pain and discomfort and nutritional disorders, and need symptomatic treatment of pain symptoms, they can take ibuprofen, painkillers and other pain-relieving drugs as prescribed by the doctor, and nutritional supportive therapy should be given intravenously or intestinally to ensure the nutritional intake of the patients. When the patient’s own state is good, and the condition is controlled and its treatment is effective, it is very likely to realize the clinical cure. Although the chance of cure is small in locally advanced stage of thyroid cancer, it is still recommended that patients actively cooperate with doctors for treatment, and keep a positive psychological state is more conducive to the recovery of the disease. Drugs should be applied under doctor’s guidance