The progression of celiac disease with enterocolitis can be controlled by active and standardized treatment, which is usually difficult to cure completely. Celiac disease with enterocolitis means that there is gastric mucosal erosion, and the glandular epithelial cells have been changed in morphology and function. After active treatment, the progress of the disease can be controlled, usually it is more difficult to cure, but also need to actively give standardized treatment, so as to avoid deterioration of the condition. For patients with clinical erosion with intestinalization, acid inhibitors, such as omeprazole, rabeprazole, pantoprazole and so on, can be given to inhibit the secretion of gastric acid, and at the same time, combined with the application of gastric mucous membrane protection agents, such as aluminum thioglycollate, sodium bicarbonate, magnesium aluminium carbonate chewable tablets and so on to promote the repair of gastric mucous membrane, and the condition can be stabilized after active treatment to lower the chances of cancerous transformation. Patients should pay attention to regular review of gastroscopy to observe the progress of the disease, and if cancer occurs, surgical resection is necessary. When celiac disease with intestinalization is found, patients should standardize the medication under the guidance of physicians, and should not use medication indiscriminately on their own. Meanwhile, they should regulate their emotions and avoid excessive tension and anxiety, and most of them can be controlled after active treatment.