HFMD is the vaccination of hand, foot and mouth disease, and the common adverse reactions include redness, hardness, pain, fever, loss of appetite, nausea and so on. HFMD vaccine belongs to Class II vaccine, which is fully known as enterovirus 71 inactivated vaccine. According to relevant clinical studies, some people may have localized symptoms such as redness, hardness, pain, etc. after receiving HFMD vaccine, but it can be relieved on its own within three days under normal circumstances. In addition, people vaccinated with HFMD vaccine may also experience systemic symptoms such as fever, loss of appetite, nausea, irritability, fatigue, vomiting and diarrhea. Usually, it is a transient adverse reaction and can go away on its own after a period of time. Since the safety of this vaccine is good, the symptoms of adverse reactions are usually mild and no serious discomfort will occur. HFMD vaccine is mainly used to prevent HFMD caused by enterovirus 71, and infants and children aged 6 months to 5 years are the target population for this vaccine. In conclusion, after receiving the HFMD vaccine, you need to strengthen your daily life management, and go to the hospital promptly if the symptoms do not subside after a long period of time.