Cough with weight loss is usually one of the symptoms of tuberculosis, a chronic infectious disease caused by Mycobacterium tuberculosis, which can affect many organs, with tuberculosis infection of the lungs being the most common. The most common form of tuberculosis infection is in the lungs. People who excrete the bacilli are an important source of infection. Infection with Mycobacterium tuberculosis does not necessarily cause morbidity, but may cause clinical morbidity when resistance is reduced or cell-mediated metaplasia is increased. If diagnosed promptly and treated appropriately, most cases can be cured clinically. Since the 1990s, tuberculosis, which had been under control, has become a widespread epidemic worldwide. The fight against tuberculosis has entered a new era. Tuberculosis bacilli that are resistant to certain drugs are more difficult to treat, so prevention of tuberculosis is very important. When you have unexplained low fever, lethargy, weakness, cough, night sweats, and no other cause is detected, you should go to the hospital quickly to check and confirm the diagnosis. Regular and full course of medication should be administered under the guidance of a specialist, and the course of treatment should not be shorter than six months, and patients should be patient enough. Rest, adequate nutrition, appropriate outdoor activities and strengthening of systemic resistance are still important conditions to overcome the disease. Patients should be properly isolated during the elimination period, and it is important to protect the health of family members and the collective population, especially children.