Horizontal stripes on the surface of the toenail may be related to ringworm of the nail, lichen planus, psoriasis nail and other diseases, and in the treatment of which antifungal, immunomodulator and glucocorticoid drugs need to be given respectively. 1. Ringworm of the nails: toenails infected with ringworm, due to the destruction of the keratin protein of the toenail caused by ringworm, resulting in damage to the toenail, manifested as thickening of the toenail, the surface roughness, toenail vertical lines, horizontal lines, or discoloration of the toenail and so on, in the treatment of which you need to give some highly effective anti-fungal drugs, such as topical amorphophallus powder, oral fluconazole capsules and so on. 2. Nail lichen planus: lichen planus is a kind of chronic inflammatory skin disease, which can involve the toenails and lead to thickening, roughness, transverse lines, atrophy and unevenness of the nail plate, etc. In the treatment of this disease, you can choose some strong glucocorticosteroid medication, such as betamethasone cream. 3. Psoriasis nails: when psoriasis involves toenails, it will also lead to thickening of toenails and change of toenail morphology, etc. In terms of treatment, it can be combined with glucocorticosteroid drugs (triamcinolone acetonide), calcium-modulated phosphatase inhibitors (tacrolimus), biological agents (stavudine) and other medications. Due to the complexity of the cause of the disease, it is necessary to consult a doctor first to clarify the cause of the disease and then treat the symptoms. The above drugs should be used according to the doctor’s prescription.