Most of the causes of high urine bacterial culture bacteria 500/ml are due to urinary tract infections. Common causes are urethritis, cystitis, pyelonephritis and other urinary tract infectious diseases, pathogenic bacteria from the urethra into the body, may cause inflammation of the urinary bladder, if the infection is more serious and may cause pyelonephritis, which will lead to an increase in the number of pathogenic microorganisms in the urine, resulting in an abnormal urine bacterial culture test results, most of them will also be accompanied by lumbar pain, abdominal pain, frequency, urgency of urine, cloudy urine, urinary pain, urine blood Symptoms. Diagnosed with infectious factors, should be timely combined with clinical symptoms and drug sensitivity results to choose antibiotic treatment, first of all, drink more water, eat a light diet, you can take cefixime, levofloxacin and other drugs for anti-infective treatment. It is recommended to go to the hospital for examination first, and the drugs need to be used under the guidance of professional doctors.