First of all, ankylosing spondylitis is a disease related to environment, genetics, immunity, metabolism and other related factors, which usually occurs in young men and has a relatively insidious onset. The better way to treat ankylosing spondylitis, first of all, should be early treatment, control inflammation, reduce or alleviate symptoms, maintain normal posture or optimal functional position, prevent deformity. Ankylosing spondylitis should be treated with medication, but also with functional exercises in order to maximize the prevention of spinal deformity. Medications can be non-steroidal anti-inflammatory drugs such as meloxicam or ibuprofen. Women who are pregnant or breastfeeding should pay special attention to the medication, as well as zinc thioredoxin, which also inhibits proliferation and bony changes. Methotrexate, adrenocorticotropic hormone, can be used as shock therapy, tretinoin has anti-inflammatory and analgesic properties, and drugs such as bio-based preparations can be used.