There is no best medication for itchy calves as it varies greatly from individual to individual and can be caused by physiologic and pathologic reasons such as dermatologic and systemic diseases. Its treatment often includes moisturizing creams, antihistamines and so on. 1. Physiological causes: commonly caused by dry skin in autumn and winter seasons or in the elderly, local itching symptoms can occur, so you can use appropriate moisturizing cream or body lotion such as petroleum jelly to relieve. 2. Pathologic causes: (1) Skin diseases: such as chronic eczema, the above symptoms can also occur, and can be treated with Dinaid cream, tacrolimus ointment, and antihistamines such as loratadine under the guidance of a doctor. (2) Systemic diseases: such as diabetes mellitus, can also appear limited itching of the skin, in addition to active control of blood sugar, can be appropriate use of mild moisturizing lotion skin care, if necessary, the use of glycerite lotion, ebastine and other drugs treatment. Therefore, it is recommended to go to the hospital in time when the symptoms of itchy calves appear, identify the causes, and follow the doctor’s instructions for treatment, so as not to delay the condition.