The causes of high leukocytes and protein+- in urine are divided into physiological and pathological factors, physiological factors such as specimen contamination, strenuous exercise, etc.; pathological causes may be caused by pyelonephritis, cystitis and other diseases. 1. Physiological factors: transient high leukocytes, urine protein +-, such as specimen contamination, strenuous exercise, etc., there is no need to worry too much at this time, after removing the causative factors can be restored. 2. Pathologic factors: (1) pyelonephritis: pyelonephritis is due to pathogenic microorganisms, there will be fever, urinary frequency, urgency, urinary pain and bacteriuria, etc. Urine routine examination can see high leukocytes and urine protein +-. It can be treated by drugs such as levofloxacin hydrochloride capsule and amoxicillin capsule. (2) cystitis: it is due to the retrograde entry of bacteria into the bladder leading to inflammation, there will be frequent urination, urinary urgency, painful urination and other symptoms, routine urine examination can see high urine leukocytes, urinary protein +-, which can be treated by levofloxacin, ciprofloxacin and other drugs. When there are high white blood cells in the urine and urine protein +-, it is recommended that patients go to the hospital in time to find out the cause and follow the doctor’s instructions for treatment.