There is a risk that taking entecavir tablets can lower platelets. In clinical trials, there have been instances where taking entecavir tablets during treatment has caused a drop in platelets, but the chances of this happening are low. If you need to use the drug, you should use it under the supervision of your doctor. 1. Entecavir tablets are mainly used for the treatment of chronic adult hepatitis B with active viral replication, persistent elevation of serum alanine aminotransferase, or active lesions on liver histology. Adverse reactions such as diarrhea, nausea, fatigue, and dizziness are commonly observed with use. It has been shown in experimental data to cause abnormal platelet counts, so there is a possibility of thrombocytopenia. In addition, it is contraindicated in patients with severe hepatic or renal impairment and those who are allergic to the product. 2. However, the chances of taking entecavir tablets causing thrombocytopenia are low. For patients with thrombocytopenia, entecavir tablets should be used only after a doctor’s judgment before use. If medication is required, it should be administered under a doctor’s supervision.