Weakness and drowsiness are common symptoms in diabetic patients, mainly due to poor glycemic control, high blood glucose will have a corresponding effect on various tissues and organs of the body, the effect is because blood glucose as an important component of plasma osmolality, high blood glucose will lead to high plasma osmolality, the metabolism of many tissue cells will be affected, including muscle metabolism as well as neurometabolism. If the muscle metabolism is disturbed, fatigue will occur, and if the metabolism of the central nervous system is disturbed, drowsiness will develop. Diabetic patients with poor glycemic control are susceptible to neurologic and vascular disease, especially neuropathy, which can involve various systems of the body. In this case, it is easy to combine with metabolic disorders, resulting in fatigue and drowsiness, so good control of blood glucose is very critical to improve the quality of life of patients with diabetes mellitus.