The treatment of lupus encephalopathy requires immunosuppressive therapy, which is more often used clinically as hormone therapy. Patients with acute lupus encephalopathy can be given prednisone therapy and immunosuppressive agents at the same time, but the efficacy of immunosuppressive agents is not as fast as that of hormones and the side effects are greater, so they are not preferred clinically. Commonly used immunosuppressants include cyclophosphamide, which is also used clinically in combination with shock therapy, hormone with the simultaneous application of immune preparations, and intrathecal injection therapy for patients, and methotrexate and other immunosuppressants, which can effectively pass the blood-brain barrier. Patients with lupus encephalopathy are given symptomatic treatment, and if they have seizures, they are given anti-epileptic drugs, and patients with stroke manifestations are treated with stroke drugs.