Focal glandular epithelial hyperplasia of gastric mucosa can be manifested as inflammatory hyperplasia and atypical hyperplasia, the former is a benign lesion, and the latter may have the possibility of malignant transformation. Gastric mucosal focal glandular epithelial hyperplasia may be caused by inflammatory hyperplasia, mostly due to gastritis, gastric ulcer and other diseases, can be treated by drugs, such as omeprazole and other acid-suppressing agents, bismuth potassium citrate and other mucosal protective agents for treatment, mostly benign lesions, can achieve the effect of healing through treatment. Besides, gastric mucosa focally glandular epithelial hyperplasia may be caused by atypical hyperplasia, which belongs to pre-cancerous lesions, and generally needs to be treated by surgery. It is recommended that the patient should consult the doctor in time and follow the doctor’s instructions.