Uremic edema is generally caused by water and sodium retention, and the mechanism of water and sodium retention generally has the following aspects. A. Uremia, renal failure, glomerular fibrosis, loss of function, glomerular filtration rate decreased and see less urine or no urine, so the formation of edema resulting in water and sodium retention. Diuretics such as furosemide and torasemide can be applied to diuretic and reduce edema. If the effect is not obvious, hemodialysis or peritoneal dialysis treatment can be performed. Second, if a patient on dialysis develops swelling, dialysis is considered inadequate and should be enhanced, such as dialysis twice a week, which can be changed to dialysis three times a week. Third, hypoproteinemia, patients with uremia generally have malnutrition, poor nausea, nausea and other upper gastrointestinal symptoms are more common. Therefore, patients often appear hypoproteinemia, treatment is generally given to enhance nutrition, if necessary, the infusion of albumin, for protein supplementation. Fourth, in patients with uremia, if there is swelling in one lower limb and no edema in the other limb, the possibility of lower limb thrombosis complicated by uremia should be considered, and lower limb vascular ultrasound should be given to clarify the diagnosis, and if there is lower limb thrombosis, anticoagulation can be given and interventional treatment can be given if necessary.