The main causes of headache, fatigue, and sleepiness are insomnia, anxiety, depression, anemia, and hypothyroidism. Insomnia is mainly characterized by difficulty in falling asleep, excessive dreaming, difficulty in falling asleep again after waking up, and early waking up. Prolonged insomnia can cause disorders of the vegetative nerve and endocrine function, and then appear dizziness, fatigue and sleepiness. Anxiety and depression patients are mainly characterized by depressed mood, irritability, decreased interest in the surrounding things, always feel that something bad is happening, and restlessness. Severe cases can have panic, chest tightness, sweating and other somatization symptoms. Anemia is often accompanied by pallor, fatigue, decreased endurance, panic and shortness of breath. Routine blood tests suggest a decreased red blood cell count and low hemoglobin levels. Hypothyroidism is most common in post-thyroidectomy and thyroiditis patients, patients show chills, loss of appetite, bradycardia and fatigue, etc. Thyroid function often suggests a decrease in T3T4 as well as an increase in TS.