Gastroscopy is the gold standard for the examination of gastrointestinal diseases. At present, only gastroscopy can guarantee the maximum quality of examination and achieve early and clear diagnosis of gastrointestinal diseases, especially neoplastic diseases, and reduce leakage and misdiagnosis. However, in view of the discomfort that gastroscopy may bring to patients, many patients refuse to undergo this examination, resulting in delayed diagnosis of the disease, thus causing unnecessary pain and irreparable damage to themselves and their families. In recent years, as the national activities of establishing pain-free hospitals are being carried out, the pain-free state of clinical treatment and operation, including pain-free gastroscopy, has received more and more attention and concern. Moreover, the gastroenterology department of our hospital took the lead in carrying out painless gastroscopy in 2003. Painless gastroscopy is a procedure in which sedatives are appropriately applied during gastroscopy so that the patient can complete the examination or treatment under awake sedation or light sleep. Since the whole process of painless gastroscopy is comfortable and painless for patients, it only takes a few minutes and patients are awake immediately after the examination, so it is popular among patients. Since there is no discomfort and no memory of the examination process, many patients ask the doctor after the examination, “Why do you let me go before you examine me?” The doctor will ask “Why did you let me go before the examination?”. Some patients also said, “In the past, general gastroscopy was very painful, but I didn’t expect painless gastroscopy and colonoscopy to be so comfortable, so I won’t be afraid of future review.