Transaminases of 130 U/L suggest that the diagnostic criteria for liver injury have been reached and are more severe. Transaminases above 80 U/L are considered severely elevated. Above 130 U/L, the patient is considered to be suffering from a hepatic disease and has developed liver injury. It may be viral hepatitis, alcoholic liver disease and drug liver injury. 1. Viral hepatitis: When transaminases are elevated due to hepatitis viruses, antiviral medications such as entecavir should be taken under doctor’s supervision. 2. Alcoholic Liver Disease: Liver cell necrosis caused by severe alcohol abuse, which leads to abnormal elevation of aminotransferases. Patients with alcoholic liver disease need to strictly abstain from alcohol and pay attention to nutritional intake. 3. Pharmacological liver injury: certain medications can also cause abnormal elevation of aminotransferases. At this time, you need to stop taking the medication immediately and go to the hospital for further treatment. It is recommended to go to the hospital for further examination, after clarifying the cause of the disease, under the guidance of the doctor for treatment.