Blood sugar can not be lowered, mainly because the diet is not controlled, sugar intake is too much, the choice of hypoglycemic drugs is not correct, the dose is not right. 1, to carry out the control of diet, sugar control, strengthen physical exercise. 2, in the oral hypoglycemic drugs, preferred metformin extended-release tablets, the general maximum dose is 2000mg, once a day, some people only use 1-2 tablets, the effect is not good. 3, if the postprandial blood sugar is very high, you can increase the dose of metformin and acarbose, you can use 2 tablets each time, 3 times a day. If oral hypoglycemic drugs are still not controlled, insulin should be used for treatment as soon as possible. There are many insulin treatment options, the most common at present, is insulin at three meals, plus basal insulin for treatment, which can adjust the blood sugar of three meals, but also adjust the average blood sugar. 4, choose premixed insulin, use 2 times a day, 1 time in the morning and 1 time in the evening, the dose is based on the blood sugar situation, for continuous adjustment.