If there is a bump next to the vagina, it is often clinically caused by the following reasons. First, if the bump itself is locally red and swollen, with significant pain when touched with the hand. This is often due to an acute inflammation of the vulva, causing a localized boil. It can be treated with local application of Bactrim or Erythromycin ointment after washing. The second, if the vaginal side of a bump, grayish-white appearance, and like cauliflower, often genital warts, accompanied by vulvar itching and increased vaginal discharge. This is a good way to get the most out of your life.