Crizal, or lopinavir ritonavir tablets, is a drug used to treat HIV infection. After taking it for almost a month and still having diarrhea, it is considered to be an adverse reaction caused by the drug, or the patient himself may have other diseases that can lead to diarrhea such as enteritis. 1. Adverse drug reactions: From the instructions of the drug, it is known that patients may experience adverse reactions such as diarrhea, nausea and vomiting after taking lopinavir ritonavir tablets. For this situation, it is recommended that patients consult with the doctor, if necessary, need to stop the drug to choose other drugs for treatment. 2. Diarrhea caused by other diseases: the symptoms of diarrhea may not be related to the use of drugs, Crohn’s disease, chronic enteritis and other diseases, may lead to long-term diarrhea. This kind of situation patients need to carry out the necessary tests such as colonoscopy, blood routine and so on to clarify the specific situation, and then targeted to carry out treatment. It is recommended that patients go to the hospital in a timely manner, cooperate with the doctor to complete the necessary examinations, to clarify the specific causes of diarrhea, and actively carry out treatment to avoid further development of the condition.