A horn pregnancy is a pregnancy in which the embryo is implanted in the uterine cavity near the junction of the uterus and the opening of the fallopian tubes. As the pregnancy continues in the horn of the uterus, it can progress to the uterine cavity as the gestational cycle progresses, or it can grow outward at the horn of the uterus towards the fallopian tubes. This may lead to miscarriage, preterm labor, partial placental implantation, and postpartum placental retention due to the weakness of the horn muscles and lining of the uterus. For those who grow towards the fallopian tube, as the gestational week increases, the fallopian tube is even thinner due to the horn of the uterus and the combination of uterine vessels with ovarian arteries and veins and fallopian tube vessels, which is prone to rupture and bleeding, or even hemorrhage and shock, endangering the life of the mother and child. Once the diagnosis of horn pregnancy is made, different treatment measures should be chosen taking into account the ultrasound and the number of pregnancies, age, embryo survival, rupture or not and the fertility requirements of the patient. For early pregnancy without rupture, MTX or mifepristone combined with misoprostol may be used for conservative treatment, or for clearance or laparoscopic surgery; 2. For ruptured horn of the uterus and intra-abdominal bleeding, open surgery is required. For late gestation horn pregnancy, the best way to terminate the pregnancy is by cesarean section, and for normal delivery, attention should be paid to the occurrence of retained placenta at the horn of the uterus or placental implantation, and effective prevention of postpartum hemorrhage and other conditions.