The best time to take antihypertensive medication is on an empty stomach in the morning, that is, after waking up in the morning and taking it before breakfast. Because most antihypertensive drugs, including angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, calcium antagonists and diuretics, are long-acting antihypertensive drugs that can last for 24h, taking them in the morning on an empty stomach can make the effect last until the next morning. Because the lowest blood pressure in the natural physiological state of the human body occurs at night, taking antihypertensive drugs in the morning on an empty stomach allows the effect of antihypertensive drugs to be fully utilized during the day, while the blood concentration decreases at night, preventing the occurrence of hypotension at night. If the blood pressure is too low at night there will be reflex morning peak hypertension, but each person’s blood pressure fluctuates in different time periods, and the time to take antihypertensive drugs should be adjusted according to the specific situation.