The sensation of the tongue and lips are innervated by the branches of the trigeminal nerve. Possible causes for the symptoms of numbness of the tongue and mouth are trigeminal ganglion herpes zoster virus infection, aneurysm or cranial fossa meningioma compression, etc., which are listed below. 1. Trigeminal ganglion herpes zoster virus infection: after the trigeminal ganglion is infected by varicella zoster virus, symptoms of numbness in the innervated area may appear under chronic stimulation. 2. Aneurysm or cranial fossa meningioma compression: Tumors may compress the trigeminal nerve due to its growth, resulting in numbness in the innervated area of its branches. There may be other reasons for the symptoms of numbness of the tongue and mouth, it is recommended to go to the hospital in time, after clarifying the cause of the disease and early targeted treatment.