Pericoronitis of the mandibular third molar can be treated with oral anti-inflammatory medication with local irrigation, incision and drainage, and tooth extraction. 1. Oral anti-inflammatory drugs with local irrigation: commonly used drugs are amoxicillin capsules or cefixime capsules, with metronidazole or tinidazole. Local irrigation often choose 3% hydrogen peroxide solution and saline repeatedly alternating rinse the blind bag, until the blind bag has a clear liquid overflow, in the blind bag coated with iodized glycerin. 2. Incision and drainage: pericoronary inflammation is relatively large, there is a sense of fluctuation in the soft tissues around the crown, it is best to incise and drain in a timely manner, so as not to cause interstitial infection. 3. Extraction: If the third molar has recurrent pericoronitis, it is best to remove the wisdom tooth in time. In order to avoid the recurrence of pericoronitis, usually do a light diet, do not eat spicy and stimulating food, and rinse your mouth with saline or cotrimoxazole rinse after meals. If you have pericoronitis of the mandibular third molar, go to the hospital in time to avoid delaying your condition.