Lack of sweating of the extremities is most often seen in anhidrosis, including neurogenic anhidrosis, dyshidrotic anhidrosis, and idiopathic anhidrosis. It may be caused by congenital hypoplasia of sweat glands, skin lesions and nerve damage. 1. Congenital hypoplasia of sweat glands: If the patient has congenital hypoplasia or lack of sweat glands, due to the abnormal function of sweat glands, it will lead to the patient’s limbs not sweating or limited sweating. 2. Skin lesions: if the patient has more serious skin diseases, such as leprosy, scleroderma, radiation dermatitis, ichthyosis and skin atrophy, etc., it will lead to the symptoms of limited sweating, and thus no sweating of the limbs. 3. Nerve damage: In addition, when the nerve pathway that can activate the function of the sweat glands is damaged, it will also lead to abnormal function of the sweat glands of the patient, and the situation of non-sweating of the limbs may also occur. Therefore, if the affected area does not sweat, you should go to the hospital in a timely manner to clarify the cause of the disease and target treatment.