Infertility is not uncommon in families these days due to a number of environmental and dietary factors. Many of the causes of infertility are also male-related. For example, in men with oligospermia, due to the low sperm count, the sperm may be gradually depleted on a treacherous path before meeting and combining with the egg, and the chances of combining with the egg will naturally become fewer, thus leading to infertility. So is it possible to have artificial insemination with oligospermia? This is probably the biggest concern for people with oligospermia. What is oligospermia? Oligospermia is a condition in which a fertile man has a lower than normal sperm count in his semen. Under normal circumstances, the sperm count is greater than 20 million per milliliter, and the sperm count of patients with oligozoospermia is lower than this value, with mild oligozoospermia having a sperm count greater than 10 million per milliliter, moderate oligozoospermia having a sperm count greater than 5 million per milliliter, severe oligozoospermia having a sperm count of less than 5 million per milliliter, and anejaculation, which is defined as the absence of sperm in the semen when it is centrifuged on two or more occasions. What is artificial insemination? Artificial insemination (AI) is a fertility technique in which optimized semen is injected non-coitally and artificially into a woman’s reproductive tract so that the sperm and egg can freely unite for the purpose of achieving pregnancy. Since the semen is placed directly into the female reproductive tract, and the sperm will subsequently need to rely on their own strength to combine with the egg, it is required that there be a sufficient number of good sperm in the semen to increase the chances of the sperm combining with the egg, and if there are too few motile sperm and their quality is too poor, the success rate of artificial insemination will be affected. Artificial insemination will first optimize the semen of the male partner before injecting it into the female partner, which to a certain extent improves the fertilizing ability of the sperms and increases the fertility. It can be seen that mild oligozoospermia is possible to do artificial insemination, but severe oligozoospermia, weak sperm and abnormal spermatozoa are not suitable for artificial insemination. For patients with very poor sperm quality and very low chance of IUI, they can consider second generation IVF technique or donor sperm channel to help them conceive.