Bisoprolol is a selective beta-blocker along with metoprolol and can be substituted in equal proportions, depending on whether it is a long- or short-acting formulation. The commonly used formulation is bisoprolol fumarate tablets, a long-acting formulation that can be taken orally once daily, with single tablet doses including 2.5 mg and 5 mg. Metoprolol has a similar mechanism of action to bisoprolol, and long-acting formulations include metoprolol succinate extended-release tablets, with single tablet doses consisting of 47.5 mg and 95 mg taken orally once daily. Short-acting formulations include metoprolol tartrate tablets in single tablet formulations of 25 mg and 50 mg, which are short-acting formulations taken orally anywhere from 2 to 3 times daily. Replacement of the two may be done by discontinuing the former and then using the second, not by reducing the dosage and then taking the other at the same time. For example, oral bisoprolol fumarate tablets 2.5 mg once daily can be replaced with metoprolol succinate extended-release tablets 47.5 mg once daily, with appropriate dosage increases or decreases depending on the effect of action. Bisoprolol and metoprolol can be used in the treatment of hypertension and angina pectoris and can be used to control heart rate. Both have similar adverse effects, including dizziness, headache, allergy, gastrointestinal reactions, etc. Contraindications are sick sinus node syndrome, atrioventricular block of the second or third degree, people with cardiogenic shock, allergy, etc. Drugs need to be used rationally under the guidance of a specialized doctor.