Persistent atrial fibrillation can be cured, and cures include antiarrhythmic drug reversal, electrical cardioversion, and cardiac radiofrequency ablation. Persistent atrial fibrillation is an arrhythmia that refers to recurrent episodes of atrial fibrillation lasting more than 1 week and less than 1 year, which can cause impaired heart pumping function and atrial appendage thrombosis. Atrial fibrillation drug resuscitation needs to receive warfarin effective anticoagulation therapy for 3 weeks before resuscitation drugs, resuscitation drugs including procaine, propafenone, amiodarone, etc., the success rate of resuscitation is about 60%, and resuscitation needs to receive warfarin effective anticoagulation therapy for 4 weeks after the success of resuscitation. In case of ineffective drug resuscitation, electrical resuscitation can be used. When there is a thrombus attached to the wall in the left atrium, electrical resuscitation may lead to dislodgement of the thrombus, so the use of electrical resuscitation is not recommended for atrial fibrillation with a thrombus. Cardiac radiofrequency ablation is to ablate the opening of the pulmonary veins through high-frequency electromagnetic waves, so that the abnormal signals of atrial fibrillation can be restricted in the pulmonary veins and cannot be transmitted outward, and it is often used for atrial fibrillation that cannot be reversed by medication and has recurrent episodes. Persistent atrial fibrillation is recommended to consult a doctor in time, standardized treatment, drugs should be used under the guidance of a professional doctor.