1, muscle disease often need to do what tests? Tests needed when muscle disease is suspected: muscle enzyme profile tests, including serum creatine myokinase (CK), lactate dehydrogenase. normal CK does not rule out neuromuscular disease. Some neuromuscular diseases have normal or only mildly elevated CK levels. Altered permeability of the muscle fiber membrane or disruption of the membrane releases large amounts of creatine kinase from the muscle fiber into the bloodstream. Therefore elevation of serum creatine kinase is often seen in myogenic damage. In general, CK is normal or mildly elevated in neurogenic skeletal muscle injury. In contrast, CK is often not elevated or slightly elevated in patients with congenital myopathy. Laboratory tests also include examination of immune markers, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), antinuclear antibody profile (ANA profile), antineutrophil cytoplasmic antibody profile (ANCA profile), and anti-extractable nuclear antigen antibody profile (ENA profile), to rule out muscle disease due to connective tissue disease. Screening of tumor markers to rule out paraneoplastic syndrome; examination of thyroid function to rule out muscle disease due to thyroid dysfunction, etc. Electromyography, which helps to identify neurogenic and myogenic injuries, is a powerful tool for the diagnosis of neuromuscular disease. When the diagnosis is unclear, muscle biopsy pathology is often needed to clarify the diagnosis, pathology is an indispensable means of diagnosis and differential diagnosis. 2, peripheral neuropathy often need to do what tests? Laboratory tests are required when peripheral nerve is suspected: laboratory tests such as blood glucose to exclude diabetes mellitus or abnormal glucose tolerance, except for the most common diabetic peripheral neuropathy; folic acid and vitamin B12 to exclude nutritional deficiencies; immune indexes such as ESR, CRP, ANA profile, ANCA profile, ENA profile, etc. to exclude peripheral neuropathy due to connective tissue disease. Screening of tumor markers to exclude peripheral neuropathy due to paraneoplastic syndrome; examination of thyroid function to exclude peripheral neuropathy due to thyroid dysfunction. Neuroelectrical neurological examination such as electromyography and nerve conduction velocity to clarify the presence or absence of peripheral nerve damage and the localization of peripheral nerve injury. Sometimes lumbar puncture of cerebrospinal fluid is required to rule out inflammatory peripheral neuropathy. When the diagnosis is unclear, pathological examination such as nerve and skin biopsy is often needed to clarify the diagnosis. 3.How to diagnose neuromuscular disease? The diagnosis of neuromuscular disease cannot be made without detailed medical history, family history, physical examination and auxiliary examination. The diagnostic procedure of neuromuscular disease: neurologists take detailed medical history and conduct careful neurological examination, make localized and qualitative diagnosis according to the clinical symptoms and signs, and then select the auxiliary examination items in a targeted manner. Commonly used auxiliary examination items include laboratory tests, electromyography, etc. If necessary, pathological examinations such as nerve, muscle and skin biopsies should be done to further clarify the cause. After the initial diagnosis of the disease, genetic examination can be performed if necessary. 4.Can neuromuscular disease be treated? Most peripheral neuropathies, myasthenia gravis, polymyositis, periodic paralysis and poisoning, metabolic muscular diseases, etc., can be cured if diagnosed and treated correctly in time; however, some neuromuscular diseases such as hereditary peripheral neuropathy and progressive muscular dystrophy have no special treatment method yet. However, if the diagnosis is confirmed, the economic loss caused by the transfer of medical treatment can be avoided; genetic counseling and prenatal diagnosis can be used to prevent the birth of another child with the disease in the family; and once a new effective treatment method is available, the treatment opportunity will be given priority.