Whether or not a high creatinine bottle can be given is related to the cause of the creatinine increase and the medication contained in the bottle. Generally, it is possible to give a bottle, but some of the medications need to be reduced in dosage or discontinued according to the creatinine level. High creatinine can be seen in short-term eating a large amount of meat, strenuous exercise and other physiological conditions, at this time generally can be suspended. At the same time, high creatinine is also mainly seen in kidney disease, mainly due to the decline in excretion and metabolic function of the kidneys, the main clinical manifestation of water, metabolites such as creatinine, urea retention. With renal disease, the body’s excretion and metabolic rate of drugs is also reduced, the proportion of drugs and protein binding decreased, the amount of free drugs in the blood increased accordingly, which can lead to increased plasma drug concentration and central nervous and gastrointestinal reactions. When some drugs are used in patients with renal disease, it is necessary to reduce the dose of the drug and prolong the duration of administration according to the creatinine level, for example, levofloxacin, the initial dose of patients with chronic kidney disease is the normal routine dose, and then reduce the dose by 50%. In addition, drugs with nephrotoxicity, such as streptomycin, are generally not recommended when creatinine is high. When patients with high creatinine need to take bottles, it is recommended to go to regular hospitals for consultation, and choose the appropriate drugs and treatment plan according to the level of renal function under the guidance of doctors.