Plasma transfusion is usually possible in patients with liver failure. Patients with liver failure will trigger coagulation disorders, leading to a decrease in the synthetic function of the liver, causing a decrease in the synthesis of coagulation factors, which may lead to some bleeding tendencies. Plasma transfusion can replenish the body’s necessary albumin, coagulation factors and other biologically active substances to help patients maintain the body’s plasma balance and correct the occurrence of bleeding. Liver failure means that the function of liver can not meet the normal needs of the body, mainly caused by viral infection, alcohol, drugs and other causes of severe liver damage, is a critical disease of the liver. Therefore, for patients with liver failure, plasma transfusion can be used to achieve therapeutic effects. During the process of plasma transfusion, the speed of transfusion should not be too fast, and patients should closely observe whether obvious adverse reactions occur, and if there are any uncomfortable symptoms, the transfusion needs to be discontinued and under the advice of the doctor to carry out reasonable treatment.