Migraine is a common recurrent headache disorder, mainly manifesting as severe unilateral or bilateral throbbing head pain, accompanied by photophobia, nausea, vomiting and other symptoms. Globally, the incidence of migraine is about 14.7%, which is the third most common disease in the world. In addition, according to clinical statistics, the incidence of migraine is much higher in women than in men. Many migraine sufferers, after suffering from the disease, medication has become the main means to relieve their symptoms. So, what are the medications available to treat migraine? Acute phase medications are generally used for patients with high frequency of attacks and severe conditions. Patients also need to choose specific or non-specific medication under the advice of professional doctors when using medication. The main purpose of the preventive phase medication is to reduce migraine attacks and relieve symptoms through beta-blockers, antiepileptic drugs, antidepressants, calcium channel antagonists, etc. Mild patients can get significant improvement in symptoms after trying medication, but for some severe patients, the ideal effect may not be achieved. At this time, patients will think, “Migraine, besides taking medication, can we also do minimally invasive surgery? In fact, surgical procedures can be further considered for long-term medication that is not effective and for intractable migraine. In recent years, with the continuous progress of society and medicine, people have made great breakthroughs in the research of the etiology of migraine. Some scholars have found that migraine occurs when people are overly tired and stressed; some scholars have found that people with a family history of migraine are more likely to suffer from migraine than the general population. Other scholars believe that migraine is caused by the compression of blood vessels on nerves. Based on the theory that blood vessels are pressing on nerves, medical experts have started to try to treat migraine headaches with surgical procedures.