Dry skin on the soles of the feet can be treated with topical drugs, as follows: 1, moisturizing and nourishing treatment, lanolin, petroleum jelly, sesame oil can be applied; 2, when deeper chapping occurs, fusidic acid ointment mixed with recombinant bovine basic fibroblast growth factor gel can be selected to prevent bacterial infection and have a certain effect of promoting epidermal growth; 3, when keratinization, hypertrophy and accompanied by dry skin occurs, fluticasone propionate cream, harcinexide ointment and other strong glucocorticoid drugs can be selected to apply, which can strengthen the therapeutic effect of anti-keratinization and immunosuppression.