The etiology of acute myeloid leukemia m5 is not completely clear, and the possible causes include: biological factors, physical factors, chemical factors, genetic factors, and the regression of other blood diseases; the above factors may cause bone marrow suppression, weakening of the body’s immune function, gene mutation, breakage, recombination, and chromosomal aberrations, which may lead to developing leukemia. Autoimmune disease patients with immune disorders (biological factors); frequent or high-dose exposure to radiation people with bone marrow suppression, decreased immunity, genetic changes (physical factors); long-term exposure to benzene or benzene-containing organic solvents, chromosomal aberrations (chemical factors); Down syndrome patients with chromosomal changes (genetic factors); lymphoma, multiple myeloma, and other blood diseases regression. Acute myeloid leukemia m5 etiology still needs a lot of research, if there is an abnormal blood routine or related symptoms, timely consultation.