The difference between painkillers and anakinra is different in efficacy and treatment, different in adverse reactions, and different in contraindications. 1. the efficacy of the main treatment is different: to pain tablets is a kind of compound medication, play fever, inhibit inflammation, sedative, hypnotic, anticonvulsant, analgesic effect; used for fever and the treatment of mild and moderate pain. Anacin is a compound of antipyretic and analgesic, generally not as the first choice of medicine; used for acute hyperthermia fever, and short-term treatment of acute pain, i.e., headache, migraine, muscle pain, arthralgia, dysmenorrhea and so on. 2. Adverse effects are different: the adverse effects of analgesic tablets can lead to renal damage, the serious appearance of very papillary necrosis, uremia, or induce renal pelvis and bladder cancer, long-term use of dependence, tolerance, should not be taken for a long time. Anacin can be seen in the blood system adverse reactions, severe drug rash, anaphylaxis and so on. 3. Drug contraindications are different: go pain tablets allergic to aminopyrine, finasteride, caffeine or phenobarbital is prohibited, lactating women are prohibited; hepatic and renal insufficiency, the elderly should be used with caution. Anacin is contraindicated in children and adolescents under 18 years of age, in those who are allergic to this product or pyrazolones, in women in the late stages of breastfeeding, and in those who have a history of blood disorders; it is used with caution in women in the early and mid-pregnancy stage, and with caution in breastfeeding women and the elderly. Clinical use of painkillers and Anacin, need to be strictly in accordance with the doctor’s instructions for rational use, do not blindly buy their own medicine to take, to avoid adverse effects.