CT-guided technique is to use special instruments such as puncture needle, catheter and guidewire to reach the lesion directly under the guidance of CT to take biopsy or perform treatment inside the lesion. CT can clearly show the lesion size, shape, location, necrotic cavity area inside the lesion, and the anatomical relationship with the surrounding structures such as blood vessels, and can precisely determine the needle entry site, angle and depth to avoid damaging blood vessels, nerves and cremaster. Therefore, the safety is high and the complications are low, which can further improve the safety factor of the operation. There are two types of CT-guided techniques: Conventional CT guided (CCT) and Real time CT fluoroscopy (CTF) guided, which involves all organs of the body and has a correct biopsy rate of about 90%. CTF-guided lung puncture biopsy can avoid re-puncture in 83% to 90% of patients. Features of CT-guided CT-guided percutaneous puncture interventions differ from open and blind biopsies and other puncture interventions in that CT has some three-dimensional localization capability, i.e., the coordinates in the longitudinal direction can be determined using the laser localization lamp carried by the CT machine itself, and X- and Y-axis localization can be performed using the fence localization markers on the scan level. CT-enhanced scans provide insight into the blood supply to the lesion and the relationship of the lesion to the blood vessels. Compared with plain X-ray, CT can provide true cross-sectional images, both without images of lesions or organs overlapping each other and with details of lesions or organs. Therefore, CT-guided technique can determine the point of entry, angle and depth more precisely, avoiding damage to blood vessels, nerves and cremaster, and with its advantages of safety, accuracy, speed, ease of operation and less patient pain, it has become a clinician’s way to obtain first-level diagnosis It has become an important tool for clinicians to obtain primary diagnosis. CT-guided percutaneous biopsy is an ideal method for tumor diagnosis because it is performed under the strict monitoring of CT scan, so it has little damage to the surrounding tissues, few complications, accurate localization, and is an important reference value for treatment planning and prognosis.