Colonic melanosis is a non-inflammatory bowel disease characterized by melanin deposition in the colonic mucosa, which is essentially a large amount of lipofuscin-like material in the lamina propria of the colon. The disease is common in the elderly, and more elderly men than women. The disease occurs more often in the cecum, transverse colon, descending colon, and sigmoid colon, where fecal matter stays for a longer period of time, so the occurrence of colorectal melanosis is associated with constipation. When laxative drugs are used after constipation, the drugs also remain in the large intestine with feces, resulting in the formation of colorectal melanosis. Most scholars believe that the onset of this disease is also related to the long-term use of anthraquinone-based laxatives (such as Myrica fragrans bark, Fritillaria leaf, rhubarb, etc.). The disease often has no obvious clinical symptoms and is mostly detected by colonoscopy. Some patients may have abdominal distension, constipation and difficulty in defecation, while a small number of patients have vague pain in the lower abdomen and poor appetite. The intestinal mucosa is black, brown, or dark gray with yellow or pink margins and early lesions that are tiger skin patterned or patchy. Histopathological biopsy of the lamina propria is infiltrated with large numbers of large mononuclear cells containing brown pigment, and other layers of the intestinal wall are normal. The treatment is mainly aimed at the treatment of the cause, such as the treatment of chronic constipation and avoidance of long-term application of anthraquinone-based laxatives. The main reason for this is to avoid the long-term application of anthraquinone laxatives, etc. There is no effective drug treatment for this disease, so it is crucial to actively prevent and treat it. 1. Establish good bowel habits Normally, you should develop the habit of regular bowel movements, and concentrate on reading the newspaper, playing with your cell phone or doing other things during bowel movements. 2. Exercise such as walking, jogging, gymnastics, if there is no time, you can do more half squatting in the office, but also exercise the abdominal muscle tone, to make up for the lack of exercise. 4, the right treatment For more stubborn constipation, you should seek the help of a specialist, check and analyze the causes of constipation, according to the severity and type of constipation, the use of comprehensive treatment. The data show that the detection rate of colorectal adenoma and colorectal cancer are significantly higher in patients with colorectal melanosis than in those who are examined for non-colorectal melanosis, so patients identified as having colorectal melanosis should undergo regular colonoscopy in order to detect possible colorectal adenoma and colorectal cancer in time.