Many methods and medicines for cancer treatment have been handed down by doctors and folklore for many generations, most of which aim at attacking poison and eliminating evil. Cancer is a disease, the poison is so deep that it cannot be overcome unless it is attacked, so some poisonous products are often used, which are harsh and powerful, that is, the so-called method of attacking poison with poison. Especially for tumors on the surface of the body, it is more effective to apply drugs directly on the surface of the tumor or to make infiltrative injections on the tumor and its base to make the tumor corrode and fall off. 1.The basis of treating cancer with poison, because some poisonous drugs have special effects of eroding sores and eliminating rottenness, attacking hardness and dispersing knots, breaking blood stasis and eliminating swelling. Experimental research has confirmed that most of these drugs have direct cytotoxic effects on cancer cells. For example, arsenic in arsenic is protoplasmic poison, which can make living cells disintegrate and die; wild lily in wild lily can inhibit the synthesis of deoxyribonucleic acid (DNA) and kill cancer cells; water, alcohol or acetone extract of zebracho can inhibit the metabolism of cancer cells such as HELLA cells and human esophageal, cardia, stomach and liver cancer; castor bean is a strong inhibitor of protein synthesis in Ehrlich ascites cancer, and has a strong inhibitory effect on the synthesis of ribonucleic acid. It has a strong inhibitory effect on RNA synthesis. The positively charged quaternary amine salt in its preparation can combine with the surface of tumor cells with obvious negative charge, while its negatively charged phenolic ion group is convenient to enter the interior of positively charged tumor cells, thus exerting its anti-cancer effect. In addition, the total alkaloids of hookwort, a toxic component of the toxic herb Broken Arrow, however, have an inhibitory effect on the transplanted tumor S180 in animals. All these prove that there is a scientific basis for the application of certain toxic herbs in the treatment of cancer, and the special effects of certain toxic drugs are irreplaceable by general drugs. According to the information, there are no less than 50 kinds of toxic herbs commonly used in the treatment of cancer. Here are some of them for a brief introduction. (1) Arsenic : Pungent, hot and toxic. The active ingredient of arsenic is arsenic trioxide, and experimental studies have confirmed its role in inducing apoptosis, anti-tumor vascular proliferation and anti-tumor metastasis. The use of arsenic trioxide in the treatment of leukemia and solid tumors has been widely carried out in clinical practice, and animal experiments using it in malignant chest and ascites have also yielded clear results. Experiments have confirmed that the combination of arsenic trioxide with cisplatin or adriamycin significantly improves the anti-hepatocellular carcinoma effect both in vitro and in vivo, and the nature of the interaction is obviously synergistic and sensitizing. Malignant pleural fluid and ascites are one of the complications of advanced cancer invading the pleural and peritoneal membranes, and systemic medication is not effective. Since 2003, Professor Bai Yuxian of Department of Internal Medicine II of Heilongjiang Cancer Hospital has used arsenic trioxide, which can induce tumor cell apoptosis, anti-tumor vascular proliferation and anti-tumor metastasis, for the first time in the treatment of malignant pleural fluid and ascites, and simultaneously with systemic chemotherapy, and achieved the ideal clinical effect of augmentation and synergy. Of the 26 patients with malignant pleural fluid and ascites treated, 4 cases were treated with arsenite alone and 22 cases were treated with the combination of chemotherapeutic drugs. The results proved that arsenious acid has little toxic side effects, no significant damage to liver and kidney function, and the quality of life of patients during treatment was improved and the course of treatment was substantially shortened compared with the classical method. It was also found that after intraperitoneal injection of different doses of arsenic trioxide, no significant morphological changes were observed in the mesothelial cells of the abdominal cavity and organ surfaces, which indicated that arsenic trioxide could selectively act on cancer cells without damaging normal cells. Because of its low impact on organ function, patients with advanced cancer and those who cannot receive chemotherapy can also fully tolerate it. (2) Garlic : Pungent, sweet, warm and poisonous. It has the function of dispelling wind and swelling, detoxifying and killing insects. It is mainly used for digestive tract tumors, such as gastric cancer, liver cancer, esophageal cancer, and can also be tried for malignant lymphoma, lung cancer, etc. Lithopodium endamine salt for intravenous drip (not push), 100-150mg each time, diluted with 5% glucose solution, once a day or every other day, 1500mg for 1 course of treatment, can be continued after 1 week of discontinuation. Do not dilute with saline or glucose saline to avoid precipitation of crystals. For external use, take its bulb in appropriate amount and pound it for external application. (3) Castor seeds: sweet and flat in nature, with great toxicity when used raw, but non-toxic or less toxic when used cooked. It has inhibitory effect on Ehrlich ascites cancer, sarcoma S180, cervical cancer, and can be used for cervical cancer and skin cancer. For cervical cancer, use 3%-5% ricin cold cream or ointment for external application; for skin cancer, add 3% dimethyl sulfoxide to enhance its penetrating effect and thus improve the therapeutic effect, once a day for 1-2 months. Note: After external application of ricin to patients with cervical cancer, it may stimulate local itching and eczema, and cause systemic allergy such as laryngeal edema and allergic rash. It can be treated with anti-allergic drugs. (4) Bambusa: Pungent, cold and poisonous in nature. It functions to break blood, attack poison and disperse knots. It has inhibitory effect on sarcoma S180 and reticulocytoma, and can be clinically applied to various cancers such as esophageal cancer, lung cancer, breast cancer, liver cancer, stomach cancer, skin cancer, etc. Usage and dosage: 0.05~0.1g for internal use, 0.3~0.6g for extreme dosage, decoction after concoction or into pills and dispersal. Clinically, there are capsules or tablets made of Zanthoxylum, each tablet contains 0.25mg of Zanthoxylum, which is suitable for primary liver cancer, lung cancer, esophageal cancer, breast cancer, etc. Zebularine tablets are taken orally 1~2 tablets each time with incremental method, i.e. the first dose starts from 2 tablets per day and gradually increases to the usual amount. It is preferable to take it when eating. Drink more green tea or boiled water during taking the medicine, and give the medicine of laxative and diuretic, strengthening spleen and stomach. Note: Not to be taken by pregnant women and those with cardiac or renal insufficiency. (5) Broken intestine grass: pungent, bitter, warm, with great toxicity. Functions: Tackling toxicity, eliminating swelling, removing blood stasis and relieving pain. Mainly used for digestive tumors such as esophageal cancer, liver cancer, stomach cancer, also used for bone sarcoma, skin cancer. Usage and dosage: This product is very toxic, internal use and injection of total alkaloids must be very careful! The dried product and biological preparations (such as tablets) should be taken internally in small doses, gradually increasing to no more than 1.0g per day; intravenous injection of total alkaloids should also be started in small doses (2mg per day), gradually increasing to 10mg per day. if dizziness, diplopia and other reactions occur during the use of the drug, the drug should be discontinued immediately. This product has no accumulation of toxic effects and can be used continuously within the safe dose range. (6) Strychnine: also known as Phyllostachys nigra. Bitter and cold in nature, with great toxicity. It can promote the circulation, relieve pain and reduce swelling. Commonly used in esophageal cancer, stomach cancer, intestinal cancer, lung cancer, etc. It can be used in pills, or swallowed by sizzling for 0.06-0.3g each time, after concoction; decoction should not exceed 1.0g. This product is highly toxic and should not be taken for a long time. It is easy to be poisoned by overdose, with a “spastic smile” face, and can even lead to central respiratory paralysis and death. (7) Toadstool: sweet, pungent, warm and toxic. It can detoxify and eliminate swelling, relieve pain and open the orifice. According to research, both Chinese toadstool toxin and secondary toxin have obvious anti-tumor effects, mainly used for esophageal cancer, stomach cancer and intestinal cancer. Because of its anesthetic effect, it is most often used in the treatment of cancer pain. Dosage: 15~30mg, mostly used in pills and powder, appropriate amount for external use. Do not take too much toadstool internally, and use with caution for pregnant women. There are folk remedies for toad wine: take 5 live toads, 500ml of yellow wine, steam for 2 hours, remove the toads and take the wine, refrigerate and reserve. It is often used to treat stomach cancer, liver cancer, lung cancer, esophageal cancer, etc. In addition, commonly used toxic herbs for cancer include: whole scorpion, centipede, dung beetle, gecko, toad skin, dewberry, croton, anise lotus, one-horned lotus, anise golden disk, crow’s nest, beautiful pig’s urine bean, jade hairpin flower root, red maidenhair, dried lacquer, raw nanxing, raw semen, aconite, raw epiphyllum, coriander, dahlia, coriander, garcinia, andrographis, salammonia, etc. It is worthy of attention: certain drugs such as Euphorbiaceae wolfsbane, documented to be highly toxic, but its clinical application has not been found to have adverse effects on the heart, liver, kidney and hematopoietic system, and toxicological tests have also confirmed. It has been clinically proven that wolfsbane has certain efficacy on lung cancer, breast cancer, intestinal cancer, and glioblastoma of the brain. It is worthwhile for us to explore the application of the so-called “poison” which is similar but not toxic.