Tenderness is usually due to the following factors: 1, infectious factors, when enduring bacterial, viral, fungal and atypical pathogen infections will produce the body’s antigens, antibodies will also respond to the pathogenic microorganisms excluded from the body, there will be a tenderness, generalized weakness of the clinical symptoms. 2, tenderness is also common hypoglycemic reaction, in the person’s blood glucose is too low, there will be a softness of the body, weakness, palpitations, dizziness, The weakness of the whole body is also common in endocrine diseases such as ionic disorders, cyclic hypokalemia, hyponatremia will also appear in the clinical manifestations of weakness of the body and limbs. 3, endocrine metabolic diseases, such as hypothyroidism, adrenocortical hypoplasia, will also appear in the above symptoms. 4, rare diseases such as anemia, tuberculosis, and tumors will also appear in the symptoms of weakness of the whole body.