The time of taking oral drugs is generally divided into taking before meals, taking with meals, taking after meals, taking before bedtime, etc. Taking with meals means taking drugs and food together when eating, and the specific time of taking drugs should be judged according to the doctor’s instructions and the instructions of the drugs. It is recommended to take drugs with meals, generally to reduce the stimulation of drugs on the gastrointestinal tract and to improve the effect of drugs. 1, to reduce the stimulation of drugs on the gastrointestinal tract: If the drugs are taken in the fasting state, some drugs will cause irritation to the gastric mucosa or directly damage the gastric mucosa, causing discomfort in the gastrointestinal tract of patients. Such as the treatment of leukemia drugs such as Imatinib, after taking may cause patients to appear nausea, vomiting and other gastrointestinal reactions, with the meal to take the medication to help alleviate the irritation of the drug to the gastrointestinal tract; 2, improve the effect of drugs: taking into account the effect of drugs into the body, some digestive drugs into the body is easy to be destroyed by stomach acid, reducing the therapeutic value of drugs. And taken with meals or before meals can reduce the impact of stomach acid on the drug, better play the role of drugs, such as yeast, pancreatic enzymes, amylase, etc.. In addition, taking with meals can improve the bioavailability of drugs, such as hypoglycemic drugs metformin and acarbose, etc. Taking with meals can enhance the effect of drugs and play an effective hypoglycemic effect.