The main reasons for the stomach pain in the middle of the night are the following: 1, such as the intake of irritating food, after the stomach is cold may cause intestinal spasm, there will be obvious pain phenomenon. 2, may also be caused by intestinal inflammation, once again by the inflammation is easy to cause disease, there will be abnormal pain, you need to choose the effect of intestinal spasm to relieve the effect of drugs, should also choose to have the effect of protecting the intestinal mucosa. The main treatment is to choose antibiotics and antibiotics to protect the intestinal mucosa. 3, if there is obvious pain in the right lower abdomen, it may also be caused by appendicitis, so you should choose the ultrasound examination to clarify the condition at the first time. The current main treatment method is to choose anti-inflammatory drugs, which is a more common conservative treatment method, if the condition is more serious, you can also be treated through surgery.