The treatment of long-term drinking insanity includes abstinence from alcohol, sedation, antipsychotic treatment, hepatoprotective treatment, neurotrophic treatment and so on. 1. Alcohol cessation: When long-term alcohol consumption leads to psychosis, the first step is to gradually stop drinking. 2. Sedation: If accompanied by insomnia, irritability and other symptoms, diazepam, alprazolam and other drugs can be given. 3. Antipsychotic treatment: If it is clear that you are suffering from mental illness, you should follow the doctor’s instructions to give antipsychotic treatment, representative drugs include chlorpromazine, quetiapine, risperidone and so on. 4. Hepatoprotective treatment: Long-term drinking often leads to abnormal liver function. When liver function is impaired, drugs such as silymarin and thiopronin can be used. 5. Neurotrophic treatment: patients need to receive high doses of vitamin B1, B1, B12, folic acid and other treatments. Patients who experience psychosis as a result of prolonged drinking need to be hospitalized in a specialized hospital and treated with medications or other treatments under the guidance of a doctor.