The blistering of lips after a sleep may be caused by fire and internal fire disorder, or it may be a herpes virus infection on the lips, causing blistering of lips. Pay attention to the combination of work and rest in life, drink more water, smoke and drink less, develop good habits, maintain a healthy mood and improve resistance, you can prevent blistering of the lips. Chinese medicine believes that the imbalance of yin and yang in the body, the internal fire will be on fire, on fire for many reasons, long-term stay up late, mental stress, overwork can lead to internal heat from the internal organs imbalance, thus on fire. In addition, irregular diet, often eat spicy and stimulating food, also easy to improper diet accumulation of internal fire, resulting in a sleep up the lips blister situation. At the same time, the patient may also have symptoms such as red urine, dry mouth and dry tongue. Patients can take some Chinese medicines as prescribed by the doctor to relieve the symptoms of blistering at the corners of the mouth, such as San Huang Tablets, Huang Lian Shang Qing Tablets, Niu Huang Detoxification Tablets, etc. If herpes simplex virus causes skin mucous membrane infection, it can form ulcers or herpes-like lesions at the mouth and lips, with obvious pain, often accompanied by tingling and burning sensation. This may be caused by a recent decline in the body’s immunity and the weakened ability of the immune system to fight the virus and clear the herpes virus in a timely manner. Treatment can generally be topical acyclovir ointment, neomycin ointment, supplemented with oral vitamin C, vitamin B complex, etc. In addition, frequent touching of the blisters on the lips or piercing them should be avoided to avoid infection. If scabbing occurs later, the scab should be allowed to fall off on its own and should not be removed forcibly, which may lead to poor healing.