Hand-heart malformation syndrome i.e. cardiovascular-limb syndrome is also known as Holt-Oram syndrome, atrial-finger syndrome, upper limb cardiovascular syndrome, familial heart and upper limb defects, atrial-finger-toe hypoplasia, atrial and finger hypoplasia syndrome, etc. Typical symptoms: thumb with only soft tissue but no bone, crooked finger, field hockey stick hand, triple-jointed thumb, chondrodysplasia with skeletal deformity, etc. Diagnosis: Family survey: A family survey was conducted in cases with congenital heart disease such as atrial septal defect and hypoplasia and defects of the upper limbs, especially the thumb. There was a family with nine cases in four generations. Cardiac and pulmonary auscultation: systolic murmur with tremor, hyperactive and split second pulmonary valve sounds, systolic murmur in the pulmonary valve area or diastolic murmur in the tricuspid region were heard at the left sternal border between 2 and 3 or 3 and 4 ribs. Examination: Echocardiography, chest X-ray, cardiovascular imaging, X-ray bone examination may reveal various cardiovascular malformations and skeletal malformations, and a few may have genitourinary and gastrointestinal malformations.