Insulin treatment regimens include starting treatment regimens and intensive treatment regimens. The components of the starting regimen are: basal insulin therapy, premixed insulin therapy and combined basal + mealtime insulin therapy. The starting treatment program of insulin 1. Basal insulin therapy – Indications: When lifestyle intervention + one or more oral hypoglycemic agents still cannot bring blood glucose to the standard (HbA1c ≥ 7%), basal insulin therapy (intermediate-acting human insulin and long-acting insulin analogues) can be started and added. (1) Treatment regimen: oral hypoglycemic agents + bedtime NPH or long-acting insulin analogs once daily. The starting dose is 0.2 U/(kg-d). (2) Blood glucose monitoring: mainly detect the blood glucose before breakfast (fasting blood glucose) once a day. Blood glucose can be measured at any time if there is a manifestation of hypoglycemia. (3) Insulin adjustment program: adjust the insulin dosage according to the fasting blood glucose level, usually once every 3-5 days, and adjust 1-4 units each time until the blood glucose reaches the standard. (4) Efficacy assessment: HbA1c testing at three months and six months. 2. Premixed insulin-indications: In the case of poor glycemic control (HbA1c>7%) despite lifestyle intervention + one or more oral hypoglycemic agents, premixed insulin can be added, provided that insulin stimulants are discontinued. (1) Protocol: The starting dose is generally 0.2-0.4 U/(kg-d), distributed in a 1:1 ratio before breakfast and before dinner. (2) Blood glucose monitoring: mainly detect blood glucose before breakfast and before dinner. Blood glucose can be measured at any time if there is a manifestation of hypoglycemia. (3) Insulin adjustment program: adjust the pre-dinner insulin dose according to the pre-breakfast blood glucose and adjust the pre-breakfast insulin dose according to the pre-dinner blood glucose. Adjust once every 3-5 days, 1-4 units each time until the blood glucose reaches the standard. (4) Efficacy assessment: HbA1c testing three months and six months after basal blood glucose attainment. 3. Combined basal + mealtime insulin therapy – indications: When lifestyle intervention + one or more oral hypoglycemic agents still cannot bring blood glucose to the standard (HbA1c ≥ 7%), basal insulin therapy (medium-acting human insulin and long-acting insulin analogues) can be started. (1) Treatment regimen: oral hypoglycemic agents + bedtime NPH or long-acting insulin analogs once daily. The starting dose is 0.2 U/(kg-d). (2) Blood glucose monitoring: mainly detect the blood glucose before breakfast (fasting blood glucose) once a day. Blood glucose can be measured at any time if there is a manifestation of hypoglycemia. (3) Insulin adjustment program: adjust the insulin dosage according to the fasting blood glucose level, usually once every 3-5 days, and adjust 1-4 units each time until the blood glucose reaches the standard. (4) Efficacy assessment: HbA1c is tested at three months and six months.